Family name Serenus (Serenus 
, Серен 
) , around the globe, is a rare last name. The surname Serenus is characteristic of Kyrgyzstan, where it is a rare surname, Israel, where it is a very rare surname, and Russia. Measured by absolute frequency, it is commonest in Russia, France, and Kyrgyzstan. More frequently, Serenus is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Serenus | France, Democratic Republic of the Congo, Tanzania, United States, India |
| Серен | Kyrgyzstan, Russia, Kazakhstan, Ukraine, Armenia |
| lucius terentius serenus commander of the Cohors II Gemina Ligurum et Corsorum in 102 AD (b. 50) |
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| annaeus serenus politician (0100-0100) (b. 100) |
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| aulus septimius serenus ancient Roman poet (b. 101) |
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| quintus serenus Roman medical writer (b. 200) |
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| gaius julius serenus perfect of Ala VII Phrygum |
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| tiberius claudius serenus |
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| aelius serenus |
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