Surname Holtzhausen (Holtzhausen 
) , throughout the world, is quite a rare cognomen. The last name Holtzhausen is habitual in Sub-Saharan Africa, particularly Namibia, where it is quite a rare surname, South Africa, and Zimbabwe, where it is a rare surname.
| VARIANT | COUNTRY |
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| Holtzhausen | Zimbabwe, United Arab Emirates, South Africa, Germany, Namibia |
| johann hektor von holtzhausen DE (b. 1600) |
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| johann christoph holtzhausen DE (b. 1640) |
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| johann georg von holtzhausen DE (b. 1643) |
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| friedrich holtzhausen (b. 1674) |
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| august friedrich holtzhausen German engineer (1768-1827), DE (b. 1768) |
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christian gottlob holtzhausen DE (b. 1811) |
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| jacoba susanna holtzhausen (b. 1886) |
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deon holtzhausen South African military general officer, ZA (b. 1967) |
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| raymond holtzhausen ZA (b. 1934) |
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| alisha holtzhausen researcher (ORCID 0000-0003-3604-7401) |
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| cynthia holtzhausen Peerage person ID=213207 |
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| jan-louis holtzhausen Peerage person ID=629597 |
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| jean-louis holtzhausen Peerage person ID=629596 |
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| louis holtzhausen researcher |
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| maryka holtzhausen South African netball player, ZA (b. 1987) |
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