Last name De Leo (De Leo 
) , in the world, is quite a common cognomen. The last name De Leo is characteristic of Italy, where it is quite a common surname, Argentina, where it is quite a rare surname, and Guatemala, where it is a rare surname. Not in comparison with a country's population, this name is the most popular in Italy, Argentina, and Mexico.
| VARIANT | COUNTRY |
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| De Leo | Argentina, United States, Mexico, Italy, Guatemala |
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annibale de leo IT (b. 1739) |
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andrea de leo Italian politician (1849-1915), IT (b. 1849) |
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| antonino de leo IT (b. 1843) |
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josé andrés de leo Argentinian politician, AR (b. 1967) |
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| diego de leo Italian association football player and association football referee, IT (b. 1920) |
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| gaetano de leo Italian psychologist, IT (b. 1940) |
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| diego de leo Italian academic, doctor and psychiatrist (b. 1951) |
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| antonello de leo Italian film director and screenwriter, IT (b. 1965) |
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| maya de leo Italian historian, IT (b. 1974) |
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| alessandro de leo researcher |
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| diego de leo researcher (ORCID 0000-0001-8255-6480) |
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| vincenzo de leo researcher (ORCID 0000-0001-8522-9370) |
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| domenico de leo researcher |
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| giulio de leo herpetologist |
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| rossella de leo researcher ORCID ID = 0000-0001-7461-4003 |
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